动机：氧化应激和蛋白质损伤与200多种人类疾病相关，包括癌症、卒中、神经退行性疾病和衰老。蛋白质羧基化是一种化学上多样的氧化翻译后修饰（post-translational modification (PTM），被公认为氧化应激和蛋白质损伤的生物标志物。尽管它们是重要的，并且被大量研究，但是不存在有关羧基化蛋白质/位点的数据库/资源。由于这些信息对于生物学/医学研究非常有用，所以我们人工精选了一个实验确证的羧基化蛋白质/位点数据资源（CarbonylDB）。结果：CarbonylDB当前包括了来自21个物种的1495个羧基化蛋白质和3781个位点，其中人类、大鼠和酵母是前3个物种。我们对这些羧基化蛋白质/位点进行了进一步分析，并提出了它们的发生和占据模式。特别是血清白蛋白的羧基化位点数据提供了理解氧化蛋白修饰/损伤动力学的一种精细模型系统。

A curated data-resource of protein carbonylation sites

    Motivation:Oxidative stress and protein damage have been associated with over 200 human ailments including cancer, stroke, neuro-degenerative diseases, and aging (Fedorova et al., 2014. Mass Spectrom. Rev., 33, 79-97). Protein carbonylation, a chemically diverse oxidative post-translational modification (PTM), is widely considered as the biomarker for oxidative stress and protein damage. Despite their importance and extensive studies, no database/resource on carbonylated proteins/sites exists. As such information is very useful to research in biology/medicine, we have manually curated a data-resource (CarbonylDB) of experimentally-confirmed carbonylated proteins/sites. Results: The CarbonylDB currently contains 1495 carbonylated proteins and 3781 sites from 21 species, with human, rat, and yeast as the top three species. We have made further analyses of these carbonylated proteins/sites and presented their occurrence and occupancy patterns. Carbonylation site data on serum albumin, in particular, provides a fine model system to understand the dynamics of oxidative protein modifications/damage.

     上海恒远生物科技有限公司坐落于美丽的上海，于2008年成立，是一家生物技术企业，主要从事免疫学、分子生物学和常规生化试剂的研发及销售。主要产品有进口BIM/RD/TSZ ELISA试剂盒、NQBB/GIBCO/HYCLONE 血清、ABCAM 抗体、SIGMA/SPECTRUM/AMRESCO 生物科研试剂、USP 标准品、实验耗材等。公司目前旗下有员工500余人ELISA试剂盒年销量已突破100万盒！广受喜爱的elisa试剂盒在长期的销售实践中形成了独特的市场优势，产品齐全、价格合理、经营稳健、信息反馈及时、并能随时随地享受国外供应商*直接、*周到、*完善的售后服务。